sodium hydroxide in tetrahydrofuran 0.5 h; Ambient temperature;

1: 65 percent / bromine / CCl4 / 2 h / Heating; Irradiation 2: 60 percent / sodium iodide / N,N-dimethyl-acetamide / 4 h / 70 °C 3: 90 percent / CuBr2 / CHCl3; ethyl acetate / 2 h / Heating 4: 85 percent / aq. NaOH / tetrahydrofuran / 0.5 h / Ambient temperature View Scheme

1: 60 percent / sodium iodide / N,N-dimethyl-acetamide / 4 h / 70 °C 2: 90 percent / CuBr2 / CHCl3; ethyl acetate / 2 h / Heating 3: 85 percent / aq. NaOH / tetrahydrofuran / 0.5 h / Ambient temperature View Scheme

1: 90 percent / CuBr2 / CHCl3; ethyl acetate / 2 h / Heating 2: 85 percent / aq. NaOH / tetrahydrofuran / 0.5 h / Ambient temperature View Scheme