(S)-5-甲氧基-1,2,3,4-四氢-N-丙基-2-萘胺合成路线 （共 12 条）
反应条件
(S)-(+)-N-(3,5-dinitrobenzoyl)-α-phenylglycine in water; acetonitrile T=0 - 5°C; 2 h;
参考文献
KANDULA, Mahesh
Patent: WO2013/168033 A1, 2013 ;
Location in patent: Paragraph 0099; 00100 ;
反应条件
potassium carbonate in toluene T=60°C;
参考文献
Marquillas Olondriz, Francisco; Pomares Marco, Marta
Patent: US2011/152543 A1, 2011 ;
Location in patent: Page/Page column 3 ;
反应条件
hydrogen; acetic acid; palladium on activated charcoal in ethanol Ambient temperature;
参考文献
Seiler, Max P.; Stoll, Andre P.; Closse, Annemarie; Frick, Willy; Jaton, Annelise; Vigouret, Jean-Marie
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 912 - 917
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 42 h; Heating;
参考文献
Homan, Evert J.; Copinga, Swier; Unelius, Lena; Jackson, David M.; Wikstroem, Hkan V.; Grol, Cor J.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 7 p. 1263 - 1271
反应条件
1: 99 percent / K2CO3 / butan-2-one / 30 h / 90 °C 2: 84 percent / H2, AcOH / 10percent Pd/C / ethanol / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 6 p. 912 - 917
反应条件
1: 1.) p-TsOH, 2.) H2 / 2.) PtO2 / 1.) toluene, reflux, 2 h, 2.) EtOH, 32 psi, 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 11 p. 3235 - 3241
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 8 p. 1319 - 1329
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 11 p. 3235 - 3241
反应条件
Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 11 p. 3235 - 3241
反应条件
1.1: hydrogen bromide / acetic acid / 3 h / Reflux 1.2: pH 12.5 1.3: pH 9 - 9.5 2.1: sodium hydrogencarbonate / acetonitrile / 9 h / Reflux 2.2: pH 1 - 2 2.3: pH 7 - 7.5 View Scheme
