(S)-1-N-叔丁氧羰基-3-羟基吡咯烷合成路线 （共 24 条）
反应条件
triethylamine in 1,4-dioxane 8 h;
参考文献
Tetrahedron Letters, , vol. 37, # 13 p. 2285 - 2288
参考文献
US6335445 B1, ;
Page column 102 ;
反应条件
Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Synthetic Communications, , vol. 15, # 7 p. 587 - 598
反应条件
[bis(2-methoxyethyl)amino]-sulfur trifluoride in dichloromethane T=0 - 20°C; 1 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/69256 A1, 2004 ;
Location in patent: Page/Page column 49 ;
WO 2004/069256 A1
反应条件
pyridine in dichloromethane T=0 - 50°C; 8.25 h;
参考文献
SANOFI-AVENTIS
Patent: WO2007/93363 A1, 2007 ;
Location in patent: Page/Page column 88 ;
WO 2007/093363 A1
反应条件
1: 85 percent / pyridine / CH2Cl2 / 20 °C 2: dimethylformamide / 72 h / 110 °C 3: 4.2 g / ammonia / methanol / 0 °C 4: 90 percent / pyridine / CH2Cl2 / 20 °C View Scheme
参考文献
Kocalka, Petr; Pohl, Radek; Rejman, Dominik; Rosenberg, Ivan
Tetrahedron, 2006 , vol. 62, # 24 p. 5763 - 5774
反应条件
triethylamine; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; Cooling with ice;
参考文献
SANOFI-AVENTIS; GAO, Zhongli; HARTUNG, Ryan; STEFANY, David
Patent: WO2010/65798 A1, 2010 ;
Location in patent: Page/Page column 33-34 ;
WO 2010/065798 A1
反应条件
1: 85 percent / pyridine / CH2Cl2 / 20 °C 2: dimethylformamide / 72 h / 110 °C View Scheme
参考文献
Kocalka, Petr; Pohl, Radek; Rejman, Dominik; Rosenberg, Ivan
Tetrahedron, 2006 , vol. 62, # 24 p. 5763 - 5774
反应条件
1: 85 percent / pyridine / CH2Cl2 / 20 °C 2: dimethylformamide / 72 h / 110 °C 3: 4.2 g / ammonia / methanol / 0 °C View Scheme
参考文献
Kocalka, Petr; Pohl, Radek; Rejman, Dominik; Rosenberg, Ivan
Tetrahedron, 2006 , vol. 62, # 24 p. 5763 - 5774
反应条件
1: 85 percent / pyridine / CH2Cl2 / 20 °C 2: dimethylformamide / 72 h / 110 °C 3: 4.2 g / ammonia / methanol / 0 °C View Scheme
参考文献
Kocalka, Petr; Pohl, Radek; Rejman, Dominik; Rosenberg, Ivan
Tetrahedron, 2006 , vol. 62, # 24 p. 5763 - 5774
