(S)-1-N-叔丁氧羰基-3-羟基吡咯烷合成路线 （共 24 条）
反应条件
Dess-Martin periodane in dichloromethane T=0 - 20°C; 48 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/11284 A1, 2007 ;
Location in patent: Page/Page column 28-29 ;
WO 2007/011284 A1
反应条件
1: 93 percent / Et3N / CH2Cl2 2: 84 percent / dimethylformamide View Scheme
参考文献
GLAXOSMITHKLINE LLC; HALLMAN, Jason; LAUDEMAN, Christopher; LIU, Ronggang; MILLER, Aaron; MOORE, Michael, Lee; DOCK, Steven; MUSSO, David; PARRISH, Cynthia
Patent: WO2011/56635 A1, 2011 ;
WO 2011/056635 A1
反应条件
1: 85 percent / pyridine / CH2Cl2 / 20 °C 2: dimethylformamide / 72 h / 110 °C 3: 4.2 g / ammonia / methanol / 0 °C View Scheme
参考文献
Kocalka, Petr; Pohl, Radek; Rejman, Dominik; Rosenberg, Ivan
Tetrahedron, 2006 , vol. 62, # 24 p. 5763 - 5774
反应条件
1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 2: N,N-dimethyl-formamide / 100 °C / Inert atmosphere 3: triethylamine; hydrogen / ethanol / 20 °C / 2585.81 - 3102.97 Torr / Inert atmosphere View Scheme
参考文献
GLAXOSMITHKLINE LLC; CHAUDHARI, Amita, M.; HALLMAN, Jason; LAUDEMAN, Christopher, P.; MUSSO, David, Lee; PARRISH, Cynthia, A.
Patent: WO2011/66211 A1, 2011 ;
WO 2011/066211 A1
