(-)-(6-丙基氨基)-5,6,7,8-四氢-萘-1-醇合成路线 （共 15 条）
反应条件
1: acetonitrile; water / 2 h / 0 - 5 °C
2: potassium carbonate / toluene / 60 °C
View Scheme
参考文献
Marquillas Olondriz, Francisco; Pomares Marco, Marta
Patent: US2011/152543 A1, 2011 ;
反应条件
1.1: acetonitrile; water / 2 h / 0 - 5 °C
2.1: potassium carbonate / toluene / 60 °C
3.1: hydrogen bromide / acetic acid / 3 h / Reflux
3.2: pH 12.5
3.3: pH 9 - 9.5
View Scheme
参考文献
Marquillas Olondriz, Francisco; Pomares Marco, Marta
Patent: US2011/152543 A1, 2011 ;
反应条件
1.1: potassium carbonate / toluene / 60 °C
2.1: hydrogen bromide / acetic acid / 3 h / Reflux
2.2: pH 12.5
2.3: pH 9 - 9.5
View Scheme
参考文献
Marquillas Olondriz, Francisco; Pomares Marco, Marta
Patent: US2011/152543 A1, 2011 ;
反应条件
1.1: acetic acid / 1,2-dichloro-ethane / 0.5 h / |Inert atmosphere
1.2: 20 °C
2.1: (S)-(+)-N-(3,5-dinitrobenzoyl)-α-phenylglycine / acetonitrile; water / 2 h / 0 - 5 °C
3.1: hydrogen bromide / acetic acid / 3 h / |Reflux
4.1: sodium hydroxide / water / 40 °C / pH 12.5
View Scheme
参考文献
KANDULA, Mahesh
Patent: WO2013/168033 A1, 2013 ;
反应条件
1: (S)-(+)-N-(3,5-dinitrobenzoyl)-α-phenylglycine / acetonitrile; water / 2 h / 0 - 5 °C
2: hydrogen bromide / acetic acid / 3 h / |Reflux
3: sodium hydroxide / water / 40 °C / pH 12.5
View Scheme
参考文献
KANDULA, Mahesh
Patent: WO2013/168033 A1, 2013 ;
