1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -15 °C / |Inert atmosphere 1.2: 5.5 h / -15 - -5 °C / |Inert atmosphere 2.1: palladium diacetate; triphenylphosphine; triethylamine / N,N-dimethyl-formamide / 110 °C 3.1: caustic lye / 12 h / 120 °C View Scheme

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -15 °C / |Inert atmosphere 1.2: 5.5 h / -15 - -5 °C / |Inert atmosphere 2.1: palladium diacetate; triphenylphosphine; triethylamine / N,N-dimethyl-formamide / 110 °C 3.1: caustic lye / 12 h / 120 °C 4.1: sodium hydroxide / methanol / 1 h / 25 °C View Scheme