2-甲基-5-(1-甲基-2-吡咯烷基)吡啶合成路线 （共 11 条）
反应条件
formic acid 12 h; Heating;
参考文献
Seeman, Jeffrey I.; Secor, Henry V.; Chavdarian, Charles G.; Sanders, Edward B.; Bassfield, Ronald L.; Whidby, Jerry F.
Journal of Organic Chemistry, 1981 , vol. 46, # 15 p. 3040 - 3048
反应条件
1: conc.H2SO4 / 21 h / Heating 2: 1.) Diisopropylamine, n-BuLi/hexane, 2.) conc.HCl / 1.) ether, -70 deg C, 2.) water, reflux 3: 94 percent / sodium cyanoborohydride, 2N HCl / methanol / bromocresol green indicator 4: 81 percent / Formic Acid / 12 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 15 p. 3040 - 3048
反应条件
1: 1.) Diisopropylamine, n-BuLi/hexane, 2.) conc.HCl / 1.) ether, -70 deg C, 2.) water, reflux 2: 94 percent / sodium cyanoborohydride, 2N HCl / methanol / bromocresol green indicator 3: 81 percent / Formic Acid / 12 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 15 p. 3040 - 3048
反应条件
1: 94 percent / sodium cyanoborohydride, 2N HCl / methanol / bromocresol green indicator 2: 81 percent / Formic Acid / 12 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 15 p. 3040 - 3048
反应条件
in tetrahydrofuran T=-70°C; var. temp.; Product distribution;
参考文献
Journal of Organic Chemistry, , vol. 48, # 25 p. 4899 - 4904
反应条件
hydrogenchloride in tetrahydrofuran Heating1.) 50 deg C, 30 min, 2.) reflux, 2.5 h;
参考文献
Journal of Organic Chemistry, , vol. 48, # 25 p. 4899 - 4904
反应条件
1: 1.) sodium hydride, 2.) conc. HCl / 1) THF, reflux, 1 h; 2) H2O, reflux, overnight 2: 1.) sodium cyanoborohydride, conc. HCl, 2.) NaBH3CN, NaOAc / 1) H2O, 45 min; 2) pH 6, H2O, 30 min View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 31, # 11 p. 875 - 888
反应条件
hydrogenchloride; sodium acetate; sodium cyanoborohydride 1) H2O, 45 min; 2) pH 6, H2O, 30 min; Yield given. Multistep reaction;
参考文献
European Journal of Medicinal Chemistry, , vol. 31, # 11 p. 875 - 888
反应条件
sulfuric acid; iron(II) sulfate
参考文献
Tetrahedron Letters, , vol. 22, # 33 p. 3151 - 3154
反应条件
1.) ether, heat, 1 h, 2.) decalin, 110 deg C, 7 h; var. solvent, var. temp., var. conc.; Product distributionMechanism;
参考文献
Journal of Organic Chemistry, , vol. 48, # 25 p. 4899 - 4904
