3,4-二氟-6-硝基苯甲酸甲酯合成路线 （共 4 条）
反应条件
sulfuric acid 48 h; Heating / reflux;
参考文献
PORTOLA PHARMACEUTICALS, INC.
Patent: WO2008/36843 A2, 2008 ;
Location in patent: Page/Page column 33 ;
WO 2008/036843 A2
反应条件
1: With thionyl chloride 17 h; Heating / reflux; 2: With triethylamine in methanol 2 h;
参考文献
US2003/229068 A1, ;
Page 55 ;
US 20030229068 A1
反应条件
in diethyl ether; ethyl acetate T=0°C; 0.166667 h;
参考文献
WO2007/87717 A1, ;
Page/Page column 63 ;
WO 2007/087717 A1
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate P=2585.81 Torr; 3 h;
参考文献
PORTOLA PHARMACEUTICALS, INC.
Patent: WO2008/36843 A2, 2008 ;
Location in patent: Page/Page column 33 ;
WO 2008/036843 A2
