(R)-3-叔丁氧羰基氨基-4-苯基丁酸合成路线 （共 10 条）
反应条件
sodium hydroxide in water T=0 - 20°C; 2.5 h;
参考文献
WO2013/64231 A1, ;
Page/Page column 55 ;
WO 2013/064231 A1
反应条件
sodium carbonate; sodium thiosulfate; silver(l) oxide in 1,4-dioxane; water 1 h; Heating;
参考文献
Hernandez; Soleilhac; Roques; Fournie-Zaluski
Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1825 - 1831
反应条件
ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile T=25°C; 1 h;
参考文献
Seki, Masahiko; Matsumoto, Kazuo
Tetrahedron Letters, 1996 , vol. 37, # 18 p. 3165 - 3168
反应条件
1: N-tert-butoxycarbonyl-D-phenylalanine With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran T=-15°C; Arndt-Eistert Homologation; 1 h; 2: diazomethane in tetrahydrofuran Arndt-Eistert Homologation; 3: With silver benzoate; silica gel in ethyl acetate T=50°C; Arndt-Eistert Homologation; 0.5 h;
参考文献
Journal of Peptide Science, , vol. 18, # 9 p. 556 - 559
反应条件
potassium hydroxide in methanol 12 h; Heating; Yield given;
参考文献
European Journal of Medicinal Chemistry, , vol. 32, # 10 p. 767 - 780
反应条件
1: pyridine / 1 h 2: dimethylsulfoxide / 24 h / 50 °C 3: 30percent KOH / methanol / 12 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 32, # 10 p. 767 - 780
反应条件
1: dimethylsulfoxide / 24 h / 50 °C 2: 30percent KOH / methanol / 12 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 32, # 10 p. 767 - 780
反应条件
1: Et3N / tetrahydrofuran; H2O 2: 86 percent / 6 molpercent RuCl3*xH2O, NaIO4 / acetonitrile; CCl4; H2O / 1 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 18 p. 3165 - 3168
反应条件
1: Et3N / tetrahydrofuran; H2O 2: 86 percent / 6 molpercent RuCl3*xH2O, NaIO4 / acetonitrile; CCl4; H2O / 1 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 18 p. 3165 - 3168
反应条件
1: triethylamine / tetrahydrofuran / 1 h / -15 °C 2: tetrahydrofuran 3: silver benzoate; silica gel / ethyl acetate / 0.5 h / 50 °C View Scheme
参考文献
Journal of Peptide Science, , vol. 18, # 9 p. 556 - 559
