1,1-双(4-甲氧基苯基)-2-丙炔-1-醇合成路线 (共 9 条)
反应条件
p-toluenesulfonic acid monohydrate in dichloromethane
参考文献
TRANSITIONS OPTICAL, INC.
Patent: US2012/156508 A1, 2012 ;
反应条件
1: trimethylsilylacetylene With n-butyllithium in tetrahydrofuran; hexane
T=-10°C; 1 h;
2: 1,1-di(p-methoxyphenyl)-ketone in tetrahydrofuran; hexane
3 h;
3: With potassium hydroxide in tetrahydrofuran; methanol; hexane
T=0 - 20°C; 0.25 h; Further stages.;
参考文献
Gabbutt, Christopher D.; Heron, B. Mark; Instone, Alicia C.; Thomas, David A.; Partington, Steven M.; Hursthouse, Michael B.; Gelbrich, Thomas
European Journal of Organic Chemistry, 2003 , # 7 p. 1220 - 1230
反应条件
1: in tetrahydrofuran; xylene; mineral oil
T=20°C; 16 h;
2: With hydrogenchloride in tetrahydrofuran; water; xylene; mineral oil
T=0°C;
参考文献
TRANSITIONS OPTICAL, INC.
Patent: EP994871 B1, 2006 ;
Location in patent: Page/Page column 13 ;
反应条件
tetrahydrofuran; potassium hydroxide
参考文献
Cadiot
Annales de Chimie (Cachan, France), 1956 , vol. <13> 1, p. 214,224
参考文献
Transitions Optical, Inc.
Patent: US5411679 A1, 1995 ;
反应条件
in tetrahydrofuran
T=40°C; Grignard reaction; 18 h; Inert atmosphere;
参考文献
Lichtenheldt, Martin; Kress, Steffen; Blechert, Siegfried
Molecules, 2012 , vol. 17, # 5 p. 5177 - 5186
反应条件
in tetrahydrofuran
T=20°C; Inert atmosphere;
参考文献
Moorthy, Jarugu Narasimha; Koner, Apurba L.; Samanta, Subhas; Roy, Ankur; Nau, Werner M.
Chemistry - A European Journal, 2009 , vol. 15, # 17 p. 4289 - 4300
反应条件
ethylenediamine in N,N-dimethyl-formamide
参考文献
Colwell,W.T. et al.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 4 p. 749 - 752
反应条件
1: AlCl3, aluminium chloride / dichloromethane / |Inert atmosphere
2: n-butyllithium / tetrahydrofuran / |Inert atmosphere
3: potassium hydroxide / methanol / |Inert atmosphere
View Scheme
参考文献
Delatouche, Regis; Denis, Iza; Grinda, Marion; Bahhaj, Fatima El; Baucher, Estelle; Collette, Floraine; Heroguez, Valerie; Gregoire, Marc; Blanquart, Christophe; Bertrand, Philippe
European Journal of Pharmaceutics and Biopharmaceutics, 2013 , vol. 85, # 3 PART B p. 862 - 872