5-溴-2-甲酰基苯甲酸甲酯合成路线 （共 10 条）
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide T=75°C; 2 h;
参考文献
Lartia, Remy; Allain, Clemence; Bordeau, Guillaume; Schmidt, Falk; Fiorini-Debuisschert, Celine; Charra, Fabrice; Teulade-Fichou, Marie-Paule
Journal of Organic Chemistry, 2008 , vol. 73, # 5 p. 1732 - 1744
反应条件
potassium carbonate in N,N-dimethyl-formamide 4 h; Reflux;
参考文献
Mirabdolbaghi, Roya; Dudding, Travis
Tetrahedron, 2013 , vol. 69, # 15 p. 3287 - 3292
反应条件
water; silver nitrate in isopropyl alcohol T=20°C; Darkness;
参考文献
Herzog, Beat; Neier, Reinhard
Arkivoc, 2011 , vol. 2011, # 6 p. 29 - 44
反应条件
potassium carbonate in acetone T=20°C; 3 h; Reflux;
参考文献
Zhang, Haoyi; Zhang, Shilei; Liu, Lu; Luo, Guangshun; Duan, Wenhu; Wang, Wei
Journal of Organic Chemistry, 2010 , vol. 75, # 2 p. 368 - 374
反应条件
1: N-bromosuccinmide; sulfuric acid; trifluoroacetic acid / 60 h / 20 °C 2: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / 1,2-dichloro-ethane / 1 h / Reflux 3: water / 1 h / Reflux 4: potassium carbonate / N,N-dimethyl-formamide / 4 h / Reflux View Scheme
参考文献
Mirabdolbaghi, Roya; Dudding, Travis
Tetrahedron, 2013 , vol. 69, # 15 p. 3287 - 3292
反应条件
1: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / 1,2-dichloro-ethane / 1 h / Reflux 2: water / 1 h / Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 4 h / Reflux View Scheme
参考文献
Mirabdolbaghi, Roya; Dudding, Travis
Tetrahedron, 2013 , vol. 69, # 15 p. 3287 - 3292
反应条件
1: water / 1 h / Reflux 2: potassium carbonate / N,N-dimethyl-formamide / 4 h / Reflux View Scheme
参考文献
Mirabdolbaghi, Roya; Dudding, Travis
Organic Letters, 2012 , vol. 14, # 14 p. 3748 - 3751
反应条件
1.1: bromine; iron / 16 h / 0 - 20 °C 1.2: 15 h / Reflux 2.1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 15 h / Reflux 3.1: water; silver nitrate / isopropyl alcohol / 20 °C / Darkness View Scheme
参考文献
Herzog, Beat; Neier, Reinhard
Arkivoc, 2011 , vol. 2011, # 6 p. 29 - 44
反应条件
1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 15 h / Reflux 2: water; silver nitrate / isopropyl alcohol / 20 °C / Darkness View Scheme
参考文献
Herzog, Beat; Neier, Reinhard
Arkivoc, 2011 , vol. 2011, # 6 p. 29 - 44
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran
T=20°C; 3 h;
参考文献
ABIDE THERAPEUTICS; THE SCRIPPS RESEARCH INSTITUTE; CISAR, Justin, S.; GRICE, Chery, A.; JONES, Todd, K.; NIPHAKIS, Micah, J.; CHANG, Jae, Won; LUM, Kenneth, M.; CRAVATT, Benjamin, F.
Patent: WO2013/103973 A1, 2013 ;
Location in patent: Paragraph 00393 ;
