C36H45Cl2N3OPd; potassium tert-butylate in 1,4-dioxane T=90°C; Buchwald-Hartwig Coupling; 1 h; Inert atmosphereSchlenk technique;

bicyclo-[2.2.1]hept-2-ene; tris(4-methoxyphenyl)-phosphine; palladium diacetate; caesium carbonate; isopropyl alcohol in toluene T=100°C; 24 h; Inert atmosphereSealed tube;

1: dipotassium hydrogenphosphate / N,N-dimethyl-formamide / 0 - 20 °C / |Inert atmosphere; |Sealed tube 2: bicyclo-[2.2.1]hept-2-ene; palladium diacetate; caesium carbonate; tris(4-methoxyphenyl)-phosphine; isopropyl alcohol / toluene / 24 h / 100 °C / |Inert atmosphere; |Sealed tube View Scheme