2-氯-3-氟-4-硝基吡啶氮氧化物合成路线 （共 13 条）
反应条件
sulfuric acid; sulfur trioxide; nitric acid 1 h; Heating;
参考文献
Liebigs Annalen der Chemie, , p. 857 - 862
反应条件
1: 64 percent / (CH3CO)2O, 30percent H2O2 / 12 h / 80 °C 2: 44 percent / conc. H2SO4/H2SO4 (20percent SO3) (1:1); H2SO4 (20percent SO3)/100percent HNO3 / 1 h / Heating View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 857 - 862
反应条件
1: 82 percent / 15percent H2O2, conc. HCl 2: 38 percent 3: 54 percent / acetic anhydride, 30percent H2O2 4: 42 percent / 100percent HNO3/ 100percent H2SO4 containing 10percent SO3 View Scheme
参考文献
Tetrahedron Letters, , vol. 26, # 40 p. 4903 - 4906
反应条件
1: 38 percent 2: 54 percent / acetic anhydride, 30percent H2O2 3: 42 percent / 100percent HNO3/ 100percent H2SO4 containing 10percent SO3 View Scheme
参考文献
Tetrahedron Letters, , vol. 26, # 40 p. 4903 - 4906
反应条件
1: 95 percent / Na / methanol / 1 h / Ambient temperature 2: 58 percent / PCl3 / CHCl3 / 2 h / Heating View Scheme
参考文献
Dehmlow, Eckehard V.; Schulz, Hans-Joachim
Liebigs Annalen der Chemie, 1987 , p. 857 - 862
反应条件
phosphorus trichoride in chloroform 2 h; Heating;
参考文献
Dehmlow, Eckehard V.; Schulz, Hans-Joachim
Liebigs Annalen der Chemie, 1987 , p. 857 - 862
反应条件
1: 83 percent / Na / methanol / 72 h / Ambient temperature 2: 80 percent / PCl3 / CHCl3 / 2 h / Heating View Scheme
参考文献
Dehmlow, Eckehard, V.; Schulz, Hans-Joachim
Tetrahedron Letters, 1985 , vol. 26, # 40 p. 4903 - 4906
反应条件
sodium; phosphorus trichoride 1.) MeOH, 24 h, room temp. 2.) chloroform, 2 h, reflux; Yield given. Multistep reaction;
参考文献
Dehmlow, Eckehard V.; Schulz, Hans-Joachim
Liebigs Annalen der Chemie, 1987 , p. 857 - 862
反应条件
1: 1.) Na, 2.) PCl3 / 1.) MeOH, 24 h, room temp. 2.) chloroform, 2 h, reflux 2: 15 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 857 - 862
反应条件
1: 1.) Na, 2.) PCl3 / 1.) MeOH, 24 h, room temp. 2.) chloroform, 2 h, reflux
2: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
3: 53 percent / 30percent H2O2, (CH3CO)2O, / 14 h / 100 °C
4: 77 percent / 33percent HBr/CH3COOH / 5 h / Heating
View Scheme
参考文献
Dehmlow, Eckehard, V.; Schulz, Hans-Joachim
Tetrahedron Letters, 1985 , vol. 26, # 40 p. 4903 - 4906
