2-氯-3-氟-4-硝基吡啶氮氧化物合成路线 （共 13 条）
反应条件
1: 1.) Na, 2.) PCl3 / 1.) MeOH, 24 h, room temp. 2.) chloroform, 2 h, reflux
2: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
View Scheme
参考文献
Dehmlow, Eckehard, V.; Schulz, Hans-Joachim
Tetrahedron Letters, 1985 , vol. 26, # 40 p. 4903 - 4906
反应条件
1: 1.) Na, 2.) PCl3 / 1.) MeOH, 24 h, room temp. 2.) chloroform, 2 h, reflux
2: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
3: 53 percent / 30percent H2O2, (CH3CO)2O, / 14 h / 100 °C
View Scheme
参考文献
Dehmlow, Eckehard, V.; Schulz, Hans-Joachim
Tetrahedron Letters, 1985 , vol. 26, # 40 p. 4903 - 4906
反应条件
1: 1.) Na, 2.) PCl3 / 1.) MeOH, 24 h, room temp. 2.) chloroform, 2 h, reflux
2: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
3: 53 percent / 30percent H2O2, (CH3CO)2O, / 14 h / 100 °C
4: 77 percent / 33percent HBr/CH3COOH / 5 h / Heating
5: 336 h / Irradiation
View Scheme
参考文献
Dehmlow, Eckehard V.; Schulz, Hans-Joachim
Liebigs Annalen der Chemie, 1987 , p. 857 - 862
