4-氯-5-甲基噻吩并[2,3-D]嘧啶-6-羧酸乙酯合成路线 （共 3 条）
反应条件
1: With N-ethyl-N,N-diisopropylamine; trichlorophosphate in toluene T=120 - 125°C; 2: With sodium hydrogencarbonate in water; toluene T=0°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2005/42537 A1, 2005 ;
Location in patent: Page/Page column 57 ;
WO 2005/042537 A1
反应条件
trichlorophosphate Vilsmeier-Haack Formylation; Cooling with iceMicrowave irradiation;
参考文献
Jain, Kishor S.; Khedkar, Vijay M.; Arya, Nikhilesh; Rane, Prasad V.; Chaskar, Pratip K.; Coutinho, Evans C.
European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 166 - 175
反应条件
1: 43 percent / 12 h / Heating 2: 76 percent / POCl3, N,N-dimethylaniline / 14 h / Heating View Scheme
参考文献
Baumgartner; Pech; Bohm
Pharmazie, 1993 , vol. 48, # 3 p. 192 - 194
