2-氨基-5-甲氧基吡啶合成路线 （共 19 条）
反应条件
1: With hydrogen bromide in water Heating / reflux; 2: With ammonia in methanol; dichloromethane
参考文献
Tibotec Pharmaceuticals Ltd.
Patent: WO2007/113290 A1, 2007 ;
Location in patent: Page/Page column 40; 42 ;
反应条件
1: With bromine in hydrogen bromide cooling; 2: With sodium nitrite 0.5 h; cooling;
参考文献
Reimann; Erdle
Pharmazie, 2000 , vol. 55, # 12 p. 907 - 912
反应条件
1: 1,4-dioxane / 20 °C 2: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol; methanol / 6 h / 20 - 60 °C View Scheme
参考文献
WO2011/53292 A1, ;
WO 2011/053292 A1
反应条件
1: With hydrogenchloride; sodium nitrite T=-5°C; 2: With hydrogenchloride; copper(l) chloride T=0 - 70°C;
参考文献
Luetzen, Arne; Hapke, Marko; Staats, Holger; Bunzen, Jens
European Journal of Organic Chemistry, 2003 , # 20 p. 3948 - 3957
反应条件
1.1: Br2 / aq. HBr / cooling 1.2: 67 percent / aq. NaNO2 / 0.5 h / cooling 2.1: BuLi / tetrahydrofuran; hexane / -105 - -100 °C 2.2: tetrahydrofuran; hexane / -100 °C View Scheme
参考文献
Reimann; Erdle
Pharmazie, 2000 , vol. 55, # 12 p. 907 - 912
反应条件
1: 59 percent / xylene / 24 h / Heating
2: 30percent HBr, AcOH / 120 h / 100 °C
View Scheme
参考文献
Lombardino, Joseph G.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 39 - 42
反应条件
sodium acetate in tetrahydrofuran; water
T=70°C; 1 h;
参考文献
Sirisoma, Nilantha; Pervin, Azra; Zhang, Hong; Jiang, Songchun; Willardsen, J. Adam; Anderson, Mark B.; Mather, Gary; Pleiman, Christopher M.; Kasibhatla, Shailaja; Tseng, Ben; Drewe, John; Cai, Sui Xiong
Journal of Medicinal Chemistry, 2009 , vol. 52, # 8 p. 2341 - 2351
反应条件
sodium hydrogencarbonate in methanol; water
2 h; Reflux;
参考文献
Thompson, Andrew M.; Blaser, Adrian; Anderson, Robert F.; Shinde, Sujata S.; Franzblau, Scott G.; Ma, Zhenkun; Denny, William A.; Palmer, Brian D.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 3 p. 637 - 645
反应条件
1: With sodium nitrite in sulfuric acid; water
T=0 - 5°C; 0.5 h;
2: With copper(II) sulfate in water
Heating;
参考文献
Van De Poel, Herve; Guillaumet, Gerald; Viaud-Massuard, Marie-Claude
Heterocycles, 2002 , vol. 57, # 1 p. 55 - 71
