2-苯基-1-吡啶-4-乙酮合成路线 （共 16 条）
反应条件
in tetrahydrofuran; diethyl ether
24 h; Heating;
参考文献
Schwarz; Hartmann; Schonenberger
Archiv der Pharmazie, 1991 , vol. 324, # 4 p. 223 - 229
反应条件
1: diisopropylamin, n-butyllithium (15 percent) / hexane; tetrahydrofuran / 1 h / -78 °C
2: tetrabutylammoniumfluorid-hydrat / hexane; tetrahydrofuran; CH2Cl2 / Ambient temperature; stirring overnight
View Scheme
参考文献
Klose, Walter; Schwarz, Katica
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 669 - 671
反应条件
1: diisopropylamin, n-butyllithium (15 percent) / hexane; tetrahydrofuran / 1 h / -78 °C
2: tetrabutylammoniumfluorid-hydrat / hexane; tetrahydrofuran; CH2Cl2 / Ambient temperature; stirring overnight
View Scheme
参考文献
Klose, Walter; Schwarz, Katica
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 669 - 671
反应条件
1: EtONa / 2.5 h / Heating
2: 2.71 g / 48percent aq. HBr / 5 h / Heating
View Scheme
参考文献
Clader, John W.; Berger, Joel G.; Burrier, Robert E.; Davis, Harry R.; Domalski, Martin; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1600 - 1607
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, a) from -78 deg C to 0 deg C, 2.5 h, b) RT, 0.5 h
2: 95 percent / formic acid / 1.5 h / 80 °C
View Scheme
参考文献
Sheldrake
Synthetic Communications, 1993 , vol. 23, # 14 p. 1967 - 1971
反应条件
potassium hydroxide; hydrazine hydrate
Wolff-Kishner reduction; Heating;
参考文献
Richter, Isabella; Minari, Jusaku; Axe, Philip; Lowe, John P.; James, Tony D.; Sakurai, Kazuo; Bull, Steven D.; Fossey, John S.
Chemical Communications, 2008 , # 9 p. 1082 - 1084
