3-氧代-3,4-二氢-2H-1,4-苯并噁嗪-5-羧酸甲酯合成路线 （共 3 条）
反应条件
N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate in chloroform T=55°C; 5 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2009/16560 A2, 2009 ;
Location in patent: Page/Page column 40; 72 ;
WO 2009/016560 A2
反应条件
1: With boron trifluoride diethyl etherate in tetrahydrofuran T=5°C; 0.333333 h; 2: With sodium tetrahydroborate in tetrahydrofuran T=5°C; 1.5 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2009/104155 A1, 2009 ;
Location in patent: Page/Page column 57 ;
WO 2009/104155 A1
反应条件
sodium hydroxide
T=20°C; 4 h;
参考文献
Ceccarelli, Simona M.; Jaeschke, Georg; Buettelmann, Bernd; Huwyler, Joerg; Kolczewski, Sabine; Peters, Jens-Uwe; Prinssen, Eric; Porter, Richard; Spooren, Will; Vieira, Eric
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1302 - 1306
