2-(3-甲氧基苯基)吗啉合成路线 （共 4 条）
反应条件
propane-1-thiol; water; lithium hydroxide hydrate in acetonitrile T=20°C; 25 h;
参考文献
ELI LILLY AND COMPANY; GONZALEZ-GARCIA, Maria Rosario; FERNANDEZ, Maria Carmen
Patent: WO2013/116065 A1, 2013 ;
Location in patent: Page/Page column 17 ;
反应条件
1: potassium carbonate / acetonitrile / 3 h / |Reflux 2: water; lithium hydroxide hydrate; propane-1-thiol / acetonitrile / 25 h / 20 °C View Scheme
参考文献
ELI LILLY AND COMPANY; GONZALEZ-GARCIA, Maria Rosario; FERNANDEZ, Maria Carmen
Patent: WO2013/116065 A1, 2013 ;
反应条件
1: N-bromosuccinmide / dichloromethane / 20 h / 0 - 20 °C 2: potassium carbonate / acetonitrile / 3 h / |Reflux 3: water; lithium hydroxide hydrate; propane-1-thiol / acetonitrile / 25 h / 20 °C View Scheme
参考文献
ELI LILLY AND COMPANY; GONZALEZ-GARCIA, Maria Rosario; FERNANDEZ, Maria Carmen
Patent: WO2013/116065 A1, 2013 ;
反应条件
1.1: chloroform; ethanol / 2.5 h / 0 - 20 °C 1.2: 2.5 h / 0 - 20 °C 2.1: triethylamine / dichloromethane / 1 h / 0 °C 3.1: potassium hydroxide / isopropyl alcohol / 20 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 5.1: hydrogen; palladium hydroxide on carbon / methanol / 20 °C / |Inert atmosphere View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BROTHERTON-PLEISS, Christine, E.; CHEN, Zhi; ERICKSON, Shawn, David; KIM, Kyungjin; LI, Hongju; QIAN, Yimin; SO, Sung-Sau; WOVKULICH, Peter, Michael; YI, Lin
Patent: WO2014/56958 A1, 2014 ;
