5,6-二羟基-7,4'-二甲氧基黄酮合成路线 （共 11 条）
反应条件
1: With boron tribromide in dichloromethane T=0°C; 0.5 h; 2: With methanol
参考文献
Twincore Zentrum für Experimentelle und Klinische Infektionsforschung GmbH; CNRS Centre National de la Recherche Scientifique; Université de Strasbourg; Pietschmann, Thomas; Haid, Sibylle; Gentzsch, Juliane; Grethe, Christina; Davioud-Charvet, Elisabeth; Lanfranchi, Don Antoine; Elhabiri, Mourad; Benlloch-Martin, Xavier
Patent: EP2641904 A1, 2013 ;
Location in patent: Paragraph 0091-0092 ;
反应条件
hydrogenchloride in water T=100°C; 1 h;
参考文献
Thang, Tran Dinh; Kuo, Ping-Chung; Yu, Chun-Shu; Shen, Yuh-Chiang; Hoa, Le Thi Mai; Thanh, Tran Van; Kuo, Yao-Haur; Yang, Mei-Lin; Wu, Tian-Shung
Archives of Pharmacal Research, 2011 , vol. 34, # 3 p. 383 - 389
反应条件
1: acetic acid; sulfuric acid / 3.5 h / 95 - 100 °C 2: lithium hydroxide hydrate / tetrahydrofuran / 2 h / 20 °C 3: boron tribromide / dichloromethane / 0.5 h / 0 °C View Scheme
参考文献
TWINCORE GMBH; CNRS; UNIVERSITÉ DE STRASBOURG; PIETSCHMANN, Thomas; HAID, Sibylle; GENTZSCH, Juliane; GRETHE, Christina; DAVIOUD-CHARVET, Elisabeth; LANFRANCHI, Don Antoine; ELHABIRI, Mourad; BENLLOCH-MARTIN, Xavier
Patent: WO2013/139487 A1, 2013 ;
反应条件
1: lithium hydroxide hydrate / tetrahydrofuran / 2 h / 20 °C 2: boron tribromide / dichloromethane / 0.5 h / 0 °C View Scheme
参考文献
TWINCORE GMBH; CNRS; UNIVERSITÉ DE STRASBOURG; PIETSCHMANN, Thomas; HAID, Sibylle; GENTZSCH, Juliane; GRETHE, Christina; DAVIOUD-CHARVET, Elisabeth; LANFRANCHI, Don Antoine; ELHABIRI, Mourad; BENLLOCH-MARTIN, Xavier
Patent: WO2013/139487 A1, 2013 ;
反应条件
1.1: sodium peroxodisulphate; sodium hydroxide / water 2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 3 h / -78 - -10 °C / |Inert atmosphere 2.2: -78 - 20 °C / |Inert atmosphere 2.3: |Cooling with ice 3.1: acetic acid; sulfuric acid / 3.5 h / 95 °C 4.1: lithium hydroxide hydrate / tetrahydrofuran; methanol / 2 h / 20 °C 5.1: magnesium bromide / acetonitrile / 3 h View Scheme
参考文献
Twincore Zentrum für Experimentelle und Klinische Infektionsforschung GmbH; CNRS Centre National de la Recherche Scientifique; Université de Strasbourg; Pietschmann, Thomas; Haid, Sibylle; Gentzsch, Juliane; Grethe, Christina; Davioud-Charvet, Elisabeth; Lanfranchi, Don Antoine; Elhabiri, Mourad; Benlloch-Martin, Xavier
Patent: EP2641904 A1, 2013 ;
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 - -10 °C 1.2: -78 - 20 °C 2.1: acetic acid; sulfuric acid / 3.5 h / 95 - 100 °C 3.1: lithium hydroxide hydrate / tetrahydrofuran / 2 h / 20 °C 4.1: boron tribromide / dichloromethane / 0.5 h / 0 °C View Scheme
参考文献
TWINCORE GMBH; CNRS; UNIVERSITÉ DE STRASBOURG; PIETSCHMANN, Thomas; HAID, Sibylle; GENTZSCH, Juliane; GRETHE, Christina; DAVIOUD-CHARVET, Elisabeth; LANFRANCHI, Don Antoine; ELHABIRI, Mourad; BENLLOCH-MARTIN, Xavier
Patent: WO2013/139487 A1, 2013 ;
反应条件
1.1: zinc; hydrogenchloride / 0.08 h 2.1: boron trifluoride diethyl etherate / 3 h / 120 °C 3.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 - -10 °C 3.2: -78 - 20 °C 4.1: acetic acid; sulfuric acid / 3.5 h / 95 - 100 °C 5.1: lithium hydroxide hydrate / tetrahydrofuran / 2 h / 20 °C 6.1: boron tribromide / dichloromethane / 0.5 h / 0 °C View Scheme
参考文献
TWINCORE GMBH; CNRS; UNIVERSITÉ DE STRASBOURG; PIETSCHMANN, Thomas; HAID, Sibylle; GENTZSCH, Juliane; GRETHE, Christina; DAVIOUD-CHARVET, Elisabeth; LANFRANCHI, Don Antoine; ELHABIRI, Mourad; BENLLOCH-MARTIN, Xavier
Patent: WO2013/139487 A1, 2013 ;
反应条件
1.1: boron trifluoride diethyl etherate / 3 h / 120 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 - -10 °C 2.2: -78 - 20 °C 3.1: acetic acid; sulfuric acid / 3.5 h / 95 - 100 °C 4.1: lithium hydroxide hydrate / tetrahydrofuran / 2 h / 20 °C 5.1: boron tribromide / dichloromethane / 0.5 h / 0 °C View Scheme
参考文献
TWINCORE GMBH; CNRS; UNIVERSITÉ DE STRASBOURG; PIETSCHMANN, Thomas; HAID, Sibylle; GENTZSCH, Juliane; GRETHE, Christina; DAVIOUD-CHARVET, Elisabeth; LANFRANCHI, Don Antoine; ELHABIRI, Mourad; BENLLOCH-MARTIN, Xavier
Patent: WO2013/139487 A1, 2013 ;
反应条件
sodium 4-methoxyphenylacetate T=180°C; unter vermindertem Druck und Erwaermen des Reaktionsprodukts mit wss.-aethanol. Kalilauge;
参考文献
Sastri; Seshadri
Proceedings - Indian Academy of Sciences, Section A, 1946 , # 23 p. 273,276
反应条件
sodium 4-methoxyphenylacetate T=180°C; unter vermindertem Druck und Erwaermen des Reaktionsprodukts mit wss.-aethanol. Kalilauge;
参考文献
Sastri; Seshadri
Proceedings - Indian Academy of Sciences, Section A, 1946 , # 23 p. 273,276
