bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride in tetrahydrofuran T=55 - 60°C;

1: 3-bromo-5-pyridine-carboxylic acid With resin-bound amine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate in N,N-dimethyl-formamide T=20°C; 18 h; 2: 3,4,5-trimethoxyphenylboronic acid With tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether Suzuki coupling; 48 h; Heating; 3: With pyridine; trifluoroacetic anhydride in dichloromethane T=20°C; 16 h;