3-苯基-5,6-二氢-4H-吡咯并[1,2-b]吡唑合成路线 （共 37 条）
反应条件
Aliquatreg; 336; sodium carbonate; bis(dibenzylideneacetone)-palladium(0); tri-cyclo-hexyl-phosphine in ethylene glycol dimethyl ether; water
T=130°C; Suzuki coupling; 1 h; Microwave irradiation;
参考文献
Ichikawa, Hayato; Watanabe, Ryo; Fujino, Yuiko; Usami, Yoshihide
Tetrahedron Letters, 2011 , vol. 52, # 34 p. 4448 - 4451
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in water; N,N-dimethyl-formamide
T=110°C; Suzuki-Miyaura Coupling; 1 h; Inert atmosphere; Catalytic behavior; TemperatureSolventReagent/catalystConcentrationTime;
参考文献
Galeta, Juraj; Tenora, Lukas; Man, Stanislav; Potacek, Milan
Tetrahedron, 2013 , vol. 69, # 34 p. 7139 - 7146
反应条件
bis-triphenylphosphine-palladium(II) chloride; phosphate potassium salt; tetrabutyl ammonium fluoride in tetrahydrofuran; ethylene glycol dimethyl ether; water
Suzuki cross-coupling; 72 h; Reflux;
参考文献
Foster, Robert S.; Huang, Jianhui; Vivat, Jerome F.; Browne, Duncan L.; Harrity, Joseph P. A.
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 19 p. 4052 - 4056
反应条件
palladium diacetate; triphenylphosphine in ethylene glycol dimethyl ether; water
24 h; Reflux;
参考文献
Usami, Yoshihide; Watanabe, Ryo; Fujino, Yuiko; Shibano, Makio; Ishida, Chihiro; Yoneyama, Hiroki; Harusawa, Shinya; Ichikawa, Hayato
Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 12 p. 1550 - 1560
反应条件
1: piperidine / acetic acid; benzene / Reflux; Dean-Stark conditions
2: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.75 h / 0 °C
3: sodium methylate / methanol / 12.5 h / 20 °C / Reflux
4: sodium amalgam; disodium hydrogenphosphate / methanol / 24 h / Inert atmosphere
View Scheme
参考文献
Kumar, Rahul; Namboothiri, Irishi N. N.
Organic Letters, 2011 , vol. 13, # 15 p. 4016 - 4019
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 20 °C
2: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.75 h / 0 °C
3: sodium methylate / methanol / 12 h / Reflux
4: sodium amalgam; disodium hydrogenphosphate / methanol / 24 h / Inert atmosphere
View Scheme
参考文献
Kumar, Rahul; Namboothiri, Irishi N. N.
Organic Letters, 2011 , vol. 13, # 15 p. 4016 - 4019
反应条件
1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.75 h / 0 °C
2: sodium methylate / methanol / 12 h / Reflux
3: sodium amalgam; disodium hydrogenphosphate / methanol / 24 h / Inert atmosphere
View Scheme
参考文献
Kumar, Rahul; Namboothiri, Irishi N. N.
Organic Letters, 2011 , vol. 13, # 15 p. 4016 - 4019
反应条件
1: sodium methylate / methanol / 12.5 h / 20 °C / Reflux
2: sodium amalgam; disodium hydrogenphosphate / methanol / 24 h / Inert atmosphere
View Scheme
参考文献
Kumar, Rahul; Namboothiri, Irishi N. N.
Organic Letters, 2011 , vol. 13, # 15 p. 4016 - 4019
反应条件
2: sodium ethanolate / ethanol / 0.25 h / 20 °C
3: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 20 °C
4: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.75 h / 0 °C
5: sodium methylate / methanol / 12 h / Reflux
6: sodium amalgam; disodium hydrogenphosphate / methanol / 24 h / Inert atmosphere
View Scheme
参考文献
Kumar, Rahul; Namboothiri, Irishi N. N.
Organic Letters, 2011 , vol. 13, # 15 p. 4016 - 4019
反应条件
1: sodium ethanolate / ethanol / 0.25 h / 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 20 °C
3: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.75 h / 0 °C
4: sodium methylate / methanol / 12 h / Reflux
5: sodium amalgam; disodium hydrogenphosphate / methanol / 24 h / Inert atmosphere
View Scheme
参考文献
Kumar, Rahul; Namboothiri, Irishi N. N.
Organic Letters, 2011 , vol. 13, # 15 p. 4016 - 4019
