3-苯基-5,6-二氢-4H-吡咯并[1,2-b]吡唑合成路线 （共 37 条）
反应条件
1: in tetrahydrofuran; hexane
144 h; Reflux;
2: With sodium ethanolate in tetrahydrofuran; hexane
12 h; Reflux;
参考文献
Verma, Deepti; Kumar, Rahul; Namboothiri, Irishi N. N.
Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3482 - 3486
反应条件
hydrazine hydrate in propan-1-ol
Heating;
参考文献
Guzman-Perez; Maldonado
Synthetic Communications, 1991 , vol. 21, # 15-16 p. 1667 - 1674
反应条件
[1,3-bis(diphenylphosphino) propane] dichloronickel(II) in tetrahydrofuran
10 h; Heating;
参考文献
Kulinkovich, Oleg; Masalov, Nikolai; Tyvorskii, Vladimir; De Kimpe, Norbert; Keppens, Marian
Tetrahedron Letters, 1996 , vol. 37, # 7 p. 1095 - 1096
反应条件
sodium ethanolate in ethanol
20 h; Inert atmosphereReflux;
参考文献
Majumder, Supriyo; Gipson, Kevin R.; Staples, Richard J.; Odom, Aaron L.
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 11-12 p. 2013 - 2023
反应条件
1: 100 percent / KOH / dimethylformamide / 24 h / 20 °C
2: 38 percent / Bu3SnH; ACCN / toluene / 4 h / Heating
View Scheme
参考文献
Allin, Steven M.; Barton, William R.S.; Bowman, W.Russell; McInally, Tom
Tetrahedron Letters, 2002 , vol. 43, # 23 p. 4191 - 4193
反应条件
1: 38 percent / potassium hydroxide / aq. propan-2-ol / 4 h / Heating
2: 75 percent / bromine, sodium acetate / aq. acetic acid / 0 °C
3: 40 percent / NiCl2(dppp) / tetrahydrofuran / 10 h / Heating
View Scheme
参考文献
Kulinkovich, Oleg; Masalov, Nikolai; Tyvorskii, Vladimir; De Kimpe, Norbert; Keppens, Marian
Tetrahedron Letters, 1996 , vol. 37, # 7 p. 1095 - 1096
反应条件
1: 75 percent / bromine, sodium acetate / aq. acetic acid / 0 °C
2: 40 percent / NiCl2(dppp) / tetrahydrofuran / 10 h / Heating
View Scheme
参考文献
Kulinkovich, Oleg; Masalov, Nikolai; Tyvorskii, Vladimir; De Kimpe, Norbert; Keppens, Marian
Tetrahedron Letters, 1996 , vol. 37, # 7 p. 1095 - 1096
反应条件
1: hydrogenchloride / water / Reflux
2: Aliquatreg; 336; sodium carbonate; bis(dibenzylideneacetone)-palladium(0); tri-cyclo-hexyl-phosphine / ethylene glycol dimethyl ether; water / 1 h / 130 °C / Microwave irradiation
View Scheme
参考文献
Ichikawa, Hayato; Watanabe, Ryo; Fujino, Yuiko; Usami, Yoshihide
Tetrahedron Letters, 2011 , vol. 52, # 34 p. 4448 - 4451
反应条件
1: 98 percent / aq. NaOH / H2O; methanol
2: 100 percent / KOH / dimethylformamide / 24 h / 20 °C
3: 38 percent / Bu3SnH; ACCN / toluene / 4 h / Heating
View Scheme
参考文献
Allin, Steven M.; Barton, William R.S.; Bowman, W.Russell; McInally, Tom
Tetrahedron Letters, 2002 , vol. 43, # 23 p. 4191 - 4193
反应条件
1.1: triethylamine / dichloromethane / 0.5 h / -20 °C
2.1: 9-bora-bicyclo[3.3.1]nonane
2.2: 20 h / 20 °C
3.1: triethylamine
4.1: hydrogenchloride / water / Reflux
5.1: Aliquatreg; 336; sodium carbonate; bis(dibenzylideneacetone)-palladium(0); tri-cyclo-hexyl-phosphine / ethylene glycol dimethyl ether; water / 1 h / 130 °C / Microwave irradiation
View Scheme
参考文献
Ichikawa, Hayato; Watanabe, Ryo; Fujino, Yuiko; Usami, Yoshihide
Tetrahedron Letters, 2011 , vol. 52, # 34 p. 4448 - 4451
