4,6-二氯吲哚-2-甲酸合成路线 （共 7 条）
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran T=20°C; 18 h;
参考文献
NOVARTIS AG; JIRICEK, Jan; KONDREDDI, Ravinder Reddy; SMITH, Paul William
Patent: WO2014/37900 A1, 2014 ;
Location in patent: Paragraph 27; 28 ;
反应条件
1.1: sodium nitrite; hydrogenchloride / water / 0.5 h / -10 °C 1.2: 7 h / 4 °C 2.1: sulfuric acid / ethanol / 3 h / 20 °C 3.1: 3 h / 110 °C 4.1: lithium hydroxide hydrate; water / tetrahydrofuran / 18 h / 20 °C View Scheme
反应条件
1: sulfuric acid / ethanol / 3 h / 20 °C 2: 3 h / 110 °C 3: lithium hydroxide hydrate; water / tetrahydrofuran / 18 h / 20 °C View Scheme
反应条件
1: 3 h / 110 °C 2: lithium hydroxide hydrate; water / tetrahydrofuran / 18 h / 20 °C View Scheme
反应条件
phosphorus pentachloride in chloroform 0.5 h; Heating;
参考文献
Jansen, Michaela; Dannhardt, Gerd
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 10 p. 855 - 865
反应条件
quinoline; copper oxide-chromium oxide
参考文献
Pappalardo; Vitali
Gazzetta Chimica Italiana, 1958 , vol. 88, p. 1147,1153, 1159
反应条件
1: phosphorpentachloride / CHCl3 / 0.5 h / Heating
2: 0.97 g / aqueous ammonia solution / CHCl3 / cooling
3: 81 percent / POCl3 / 0.08 h / Heating
View Scheme
参考文献
Jansen, Michaela; Dannhardt, Gerd
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 10 p. 855 - 865
