7-溴-咪唑并[1,2-a]吡啶-3-羧酸合成路线 （共 3 条）
反应条件
1: With lithium hydroxide hydrate; water in tetrahydrofuran; ethanol T=20°C; 16 h; 2: With sulfuric acid in water pH=3; Cooling with ice-water;
参考文献
WO2011/79076 A1, ;
Page/Page column 67 ;
反应条件
1.1: benzene; ethanol / 5 h / 60 °C / Inert atmosphere 2.1: water; lithium hydroxide hydrate / ethanol; tetrahydrofuran / 16 h / 20 °C 2.2: pH 3 / Cooling with ice-water View Scheme
反应条件
1: 7-bromoimidazo[1,2-a]pyridine-3-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 16 h; 2: methanol T=20°C; 6 h; 3: With sodium hydrogencarbonate in water Saturated solution; Product distribution / selectivity;
参考文献
ARRAY BIOPHARMA INC.; BOYS, Mark Laurence; DELISLE, Robert Kirk; HICKEN, Erik James; KENNEDY, April L.; MARESKA, David A.; MARMSATER, Fredrik P.; MUNSON, Mark C.; NEWHOUSE, Brad; RAST, Bryson; RIZZI, James P.; RODRIGUEZ, Martha E.; TOPALOV, George T.; ZHAO, Qian
Patent: WO2012/82689 A1, 2012 ;
Location in patent: Page/Page column 103 ;
WO 2012/082689 A1
