7-溴-2-(氯甲基)-咪唑并[1,2-a]吡啶合成路线 (共 3 条)
反应条件
1: With thionyl chloride in dichloromethane T=20°C; 4 h; Inert atmosphere; 2: With water; sodium hydrogencarbonate in dichloromethane T=0°C;
参考文献
US2011/9444 A1, ;
Page/Page column 12 ;
US 20110009444 A1
反应条件
1: toluene / 16 h / 115 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C 3: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C View Scheme
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C 2: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C View Scheme