1: 78 percent / POCl3, ZnCl2 / 3 h / 50 °C 2: 92 percent / K2CO3, KI / dimethylformamide / 4 h / 80 °C 3: 1.) NaBH4 2.) 4 M HCl / 1.) methanol, 25 deg C, 2 h 2.) THF, 25 deg C, 1 h View Scheme

1: 78 percent / POCl3, ZnCl2 / 3 h / 50 °C 2: 92 percent / K2CO3, KI / dimethylformamide / 4 h / 80 °C 3: 1.) NaBH4 2.) 4 M HCl / 1.) methanol, 25 deg C, 2 h 2.) THF, 25 deg C, 1 h View Scheme

1: 92 percent / K2CO3, KI / dimethylformamide / 4 h / 80 °C 2: 1.) NaBH4 2.) 4 M HCl / 1.) methanol, 25 deg C, 2 h 2.) THF, 25 deg C, 1 h View Scheme

1: 96 percent / 2percent aq. NaOH / H2O / 1 h / 25 °C 2: 92 percent / K2CO3, KI / dimethylformamide / 4 h / 80 °C 3: 1.) NaBH4 2.) 4 M HCl / 1.) methanol, 25 deg C, 2 h 2.) THF, 25 deg C, 1 h View Scheme

hydrogenchloride; sodium tetrahydroborate 1.) methanol, 25 deg C, 2 h 2.) THF, 25 deg C, 1 h; Yield given. Multistep reaction;