5-{4-[2-(5-乙基-2-吡啶基)-2-羟基乙氧基]苄基}-1,3-噻唑烷-2,4-二酮合成路线 （共 22 条）
反应条件
sodium hydrogencarbonate; trifluoroacetic anhydride 1.) CH2Cl2, reflux, 2 h, 2.) THF; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5053 - 5063
反应条件
1: 1.)47percent HBr, NaNO2, 2.)Cu2O / 1.)MeOH, H2O, 5 deg C, 20 min., 2.)40 deg C 2: 70percent m-chloroperbenzoic acid / methanol / Heating 3: 80 °C 4: NaOAc / ethanol / Heating 5: 3N HCl / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 40, # 1 p. 37 - 42
反应条件
1: 70percent m-chloroperbenzoic acid / methanol / Heating 2: 80 °C 3: NaOAc / ethanol / Heating 4: 3N HCl / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 40, # 1 p. 37 - 42
反应条件
1: 80 °C 2: NaOAc / ethanol / Heating 3: 3N HCl / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 40, # 1 p. 37 - 42
反应条件
1: NaOAc / ethanol / Heating 2: 3N HCl / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 40, # 1 p. 37 - 42
反应条件
1: 0.5 h / 120 °C 2: sodium hydroxide / water / 2 h / 40 °C 3: thionyl chloride; triethylamine / dichloromethane / 1.25 h / 0 - 5 °C 4: N,N-dimethyl-formamide / 14 h / 80 °C 5: pyrrolidine / methanol / 2 h / 50 - 55 °C / |Large scale 6: sodium tetrahydroborate; dmgH2; CoCl2.6H2O / water; N,N-dimethyl-formamide / 4 h / 65 - 85 °C / |Large scale View Scheme
反应条件
1: pyrrolidine / methanol / 2 h / 50 - 55 °C / |Large scale 2: sodium tetrahydroborate; dmgH2; CoCl2.6H2O / water; N,N-dimethyl-formamide / 4 h / 65 - 85 °C / |Large scale View Scheme
反应条件
1: thionyl chloride / chloroform / 2 h / |Reflux 2: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
参考文献
Cadila Healthcare Limited; Pandey, Bipin; Lonray, Vidya Bhushan; Lohray, Braj Bhushan
Patent: US2014/88127 A1, 2014 ;
反应条件
1: thionyl chloride / chloroform / 2 h / |Reflux 2: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
参考文献
Cadila Healthcare Limited; Pandey, Bipin; Lonray, Vidya Bhushan; Lohray, Braj Bhushan
Patent: US2014/88127 A1, 2014 ;
反应条件
1: triethylamine / dichloromethane / 2 h / 0 °C 2: acetic acid; sodium tetrahydroborate / 15 h / 40 - 45 °C 3: hydrogenchloride / water; ethanol View Scheme
