5-{4-[2-(5-乙基-2-吡啶基)-2-羟基乙氧基]苄基}-1,3-噻唑烷-2,4-二酮合成路线 （共 22 条）
反应条件
1.1: thionyl chloride / chloroform / 2 h / |Reflux 2.1: zinc; acetic acid / 15 h / 25 - 30 °C 3.1: N-bromosuccinmide / tert-butyl alcohol; water / 1.5 h / 25 °C / |Large scale 3.2: 0.75 h / |Large scale 3.3: PEG 4000 / 17 h / 78 °C / |Large scale 4.1: thionyl chloride / chloroform / 1 h / |Reflux 5.1: acetic acid; piperidine / toluene / |Heating 6.1: zinc; acetic acid / methanol / 15 h / 25 - 30 °C View Scheme
参考文献
Cadila Healthcare Limited; Pandey, Bipin; Lonray, Vidya Bhushan; Lohray, Braj Bhushan
Patent: US2014/88127 A1, 2014 ;
反应条件
1: triethylamine / dichloromethane / 2 h / 0 °C 2: acetic acid; sodium tetrahydroborate / 15 h / 40 - 45 °C View Scheme
参考文献
Cadila Healthcare Limited; Pandey, Bipin; Lonray, Vidya Bhushan; Lohray, Braj Bhushan
Patent: US2014/88127 A1, 2014 ;
