2-乙酰基硫代甲基-3-(4-甲基苯甲酰)丙酸合成路线 （共 6 条）
反应条件
triethylamine in toluene T=60°C; Michael addition; 4 h;
参考文献
Noguchi, Toshiya; Onodera, Akira; Ito, Masato; Yoshida, Mamoru; Yokomori, Sadakazu
Synthetic Communications, 2003 , vol. 33, # 15 p. 2657 - 2670
反应条件
1: 68.4 percent / AlCl3 / nitrobenzene / 2 h / 50 °C 2: 74 percent / H2O; Et3N / toluene / 4 h / 60 °C View Scheme
参考文献
Kameo; Ogawa; Takeshita; Nakaike; Tomisawa; Sota
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 6 p. 2050 - 2060
反应条件
1: 68.4 percent / AlCl3 / nitrobenzene / 2 h / 50 °C 2: 74 percent / H2O; Et3N / toluene / 4 h / 60 °C View Scheme
参考文献
Kameo; Ogawa; Takeshita; Nakaike; Tomisawa; Sota
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 6 p. 2050 - 2060
反应条件
1: H2SO4 / 5 h / Heating
2: DDQ / benzene / 1.5 h / 20 °C
3: LiAlH4 / diethyl ether / 0.5 h / Heating
4: HMPA; thionyl chloride / tetrahydrofuran / 0.5 h / 20 °C
5: 18-crown-6 / acetonitrile / 20 °C
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1: H2SO4 / 5 h / Heating
2: DDQ / benzene / 1.5 h / 20 °C
3: LiAlH4 / diethyl ether / 0.5 h / Heating
4: HMPA; thionyl chloride / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1: H2SO4 / 5 h / Heating
2: DDQ / benzene / 1.5 h / 20 °C
3: LiAlH4 / diethyl ether / 0.5 h / Heating
4: HMPA; thionyl chloride / tetrahydrofuran / 0.5 h / 20 °C
5: Na / ethanol / 1.5 h / Heating
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
