(R)-1-(4-异丙基-2-硫氧代噻唑啉-3-基)乙酮合成路线 （共 4 条）
反应条件
pyridine in dichloromethane T=20°C; 2 h; Inert atmosphere;
参考文献
Yang, Zhen; Zhang, Bingbin; Zhao, Gaoyuan; Yang, Juan; Xie, Xingang; She, Xuegong
Organic Letters, 2011 , vol. 13, # 21 p. 5916 - 5919
反应条件
1: (S)-4-isopropyl-1,3-thiazolidine-2-thione With sodium hexamethyldisilazane in tetrahydrofuran T=-78°C; 2: acetic pivalic mixed anhydride in tetrahydrofuran T=-78°C; 5 h;
参考文献
Axford, Lorraine C.; Simpson, Thomas J.; Willis, Christine L.
Angewandte Chemie - International Edition, 2004 , vol. 43, # 6 p. 727 - 730
反应条件
1: potassium hydroxide / ethanol; water / 72 h / Reflux 2: sodium hydride / tetrahydrofuran / 20 °C View Scheme
参考文献
Yang, Zhen; Zhang, Bingbin; Zhao, Gaoyuan; Yang, Juan; Xie, Xingang; She, Xuegong
Organic Letters, 2011 , vol. 13, # 21 p. 5916 - 5919
反应条件
1.1: Sn(OTf)2; N-ethylpiperidine / CH2Cl2 / 4 h / -50 °C 1.2: CH2Cl2 / 14 h / -78 - -50 °C 2.1: 91 percent / imidazole / CH2Cl2 / 18 h View Scheme
参考文献
Sinz, Christopher J; Rychnovsky, Scott D
Tetrahedron, 2002 , vol. 58, # 32 p. 6561 - 6576
