8-氯-1-环丙基-6,7-二氟-1,4-二氢-4-氧代-3-喹啉羧酸合成路线 （共 6 条）
反应条件
hydrogenchloride T=110°C; 2.5 h;
参考文献
Warner-Lambert Company
Patent: US4771054 A1, 1988 ;
反应条件
1: NaH / dioxane / 2 h / Ambient temperature 2: 35percent HCl / 2.5 h / 110 °C View Scheme
参考文献
Kimura; Atarashi; Kawakami; Sato; Hayakawa
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3344 - 3352
反应条件
triethylamine in acetonitrile 1.) reflux, 3 h, 2.) room temperature, 18 h;
参考文献
Warner-Lambert Company
Patent: US4885386 A1, 1989 ;
反应条件
triethylamine in acetonitrile Heating;
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
反应条件
in N-methyl-acetamide; water; acetonitrile
参考文献
Bayer Aktiengesellschaft
Patent: US5061712 A1, 1991 ;
反应条件
1: Et3N / acetonitrile / 1.) reflux, 3 h, 2.) room temperature, 18 h 2: HCl, AcOH / 1.) 60 deg C, 4 h, 2.) room temperature, overnight View Scheme
参考文献
Sanchez, Joseph P.; Domagala, John M.; Hagen, Susan E.; Heifetz, Carl L.; Hutt, Marland P.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, p. 983 - 991
