2-溴-5-(溴甲基)吡啶合成路线 （共 21 条）
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in 1,2-dichloro-ethane T=85°C; 0.5 h;
参考文献
Ube Industries, Ltd.; SANTEN PHARMACEUTICAL CO., LTD.
Patent: EP1679308 A1, 2006 ;
Location in patent: Page/Page column 35 ;
EP 1679308 A1
反应条件
N-bromosuccinmide; triphenylphosphine in dichloromethane T=20°C; 3.5 h;
参考文献
Global Alliance for TB Drug Development
Patent: US2012/28973 A1, 2012 ;
Location in patent: Page/Page column 10 ;
反应条件
phosphorus tribromide T=160°C;
参考文献
Tietze, Lutz F.; Nordmann, Gero
Synlett, 1999 , # 3 p. 342 - 344
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in dichloromethane; water 3 h; HeatingIrradiation;
参考文献
Tetrahedron Letters, , vol. 43, # 9 p. 1697 - 1700
反应条件
sodium hydrogencarbonate in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; ethyl acetate
参考文献
Pfizer Inc
Patent: US2005/187266 A1, 2005 ;
反应条件
N-bromosuccinmide in tetrachloromethane
反应条件
N-bromosuccinmide; dibenzoyl peroxide in benzene T=60°C; Bromination; 24 h;
参考文献
Green, Jodie O.; Baird, John-Henry; Gibb, Bruce C.
Organic Letters, 2000 , vol. 2, # 24 p. 3845 - 3848
反应条件
dibenzoyl peroxide in chloroform 6 h; Heating / reflux;
参考文献
WO2003/106455 A1, ;
Page 55 ;
WO 03/106455 A1
反应条件
1: 93 percent / 1.) aq. 48percent HBr, bromine; 2.) aq. sodium nitrite / 1.) -20 deg C, 90 min; 2.) 15 deg C, 1 h 45 min 2: 31.5 percent / N-bromosuccinimide / CCl4 / 3.5 h / Heating; Irradiation View Scheme
参考文献
Synthesis, , # 1 p. 87 - 92
反应条件
lithium bromide in acetone 1 h; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 23 p. 8421 - 8439
