2-溴-5-(溴甲基)吡啶合成路线 （共 21 条）
反应条件
1: sodium tetrahydroborate; methanol / 0 °C 2: phosphorus tribromide / diethyl ether / 1 h / 20 °C View Scheme
反应条件
1: 84 percent / NaBH4, H2O / 0 °C 2: 50 percent / PBr3 / 160 °C View Scheme
参考文献
Synlett, , # 3 p. 342 - 344
反应条件
1: 95 percent / PCl5, POCl3 / 4 h / Heating 2: 84 percent / NaBH4, H2O / 0 °C 3: 50 percent / PBr3 / 160 °C View Scheme
参考文献
Synlett, , # 3 p. 342 - 344
反应条件
in N,N-dimethyl-formamide T=60°C; 0.5 h;
参考文献
Ube Industries, Ltd.; SANTEN PHARMACEUTICAL CO., LTD.
Patent: EP1679308 A1, 2006 ;
Location in patent: Page/Page column 35-36 ;
EP 1679308 A1
反应条件
in trans-1,3-dioxane; water T=20°C; 15 h;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2003/106455 A1, 2003 ;
Location in patent: Page 55-56 ;
WO 03/106455 A1
反应条件
tetrabutylammomium bromide in dichloromethane; water T=20°C; 16 h;
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
Location in patent: Paragraph 00627 ;
WO 2013/043232 A2
反应条件
in N-methyl-acetamide; water
参考文献
G. D. Searle and Co.
Patent: US5196537 A1, 1993 ;
反应条件
silver nitrate in water; acetone
参考文献
Williams, Theresa M.; Stump, Craig A.
Patent: US2002/22633 A1, 2002 ;
US 20020022633 A1
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in chloroform T=20°C; 16 h;
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 15 p. 6234 - 6247
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran
T=20°C; 1 h;
参考文献
Zhang, Nan; Wu, Biqi; Boschelli, Diane H.; Golas, Jennifer M.; Boschelli, Frank
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 17 p. 5071 - 5074
