5-氯甲基-2-甲氧基吡啶合成路线 （共 7 条）
反应条件
thionyl chloride in N,N-dimethyl-formamide T=0°C; 2.3 h;
参考文献
Eisai Co., Ltd.
Patent: US2006/235225 A1, 2006 ;
Location in patent: Page/Page column 4 ;
反应条件
1: With sodium tetrahydroborate in methanol T=0°C; 1 h; 2: With ammonium chloride in methanol; water
参考文献
Kyowa Hakko Kirin Co., Ltd.
Patent: EP2308880 A1, 2011 ;
Location in patent: Page/Page column 56 ;
反应条件
1: 65 percent / Ag2CO3 2: 92 percent / LiAlH4 / tetrahydrofuran 3: 71 percent / Et3N / DMAP View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 15 p. 4636 - 4645
反应条件
1: 92 percent / LiAlH4 / tetrahydrofuran 2: 71 percent / Et3N / DMAP View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 15 p. 4636 - 4645
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / -10 - 20 °C 2: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C View Scheme
参考文献
US2011/224225 A1, ;
US 20110224225 A1
反应条件
in dimethyl sulfoxide T=20°C; 18 h;
参考文献
Zeitlmann, Lutz; Niestroj, Andre; Heiser, Ulrich
Patent: US2011/224225 A1, 2011 ;
Location in patent: Page/Page column 23 ;
US 20110224225 A1
反应条件
in ethanol; water Reflux;
参考文献
Slowinski, Franck; Ben Ayad, Omar; Vache, Julien; Saady, Mourad; Leclerc, Odile; Lochead, Alistair
Journal of Organic Chemistry, 2011 , vol. 76, # 20 p. 8336 - 8346
