2-(7-羟基-2-氧代-2H-苯并吡喃-4-基)乙酰胺合成路线 （共 6 条）
反应条件
ammonia in methanol T=90°C; 60 h;
参考文献
Pisani, Leonardo; Muncipinto, Giovanni; Miscioscia, Teresa Fabiola; Nicolotti, Orazio; Leonetti, Francesco; Catto, Marco; Caccia, Carla; Salvati, Patricia; Soto-Otero, Ramon; Mendez-Alvarez, Estefania; Passeleu, Celine; Carotti, Angelo
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6685 - 6706
反应条件
ammonium hydroxide T=25°C;
参考文献
Brubaker; DeRuiter; Whitmer
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 1094 - 1099
反应条件
1: H+ 2: aq. NH3 View Scheme
参考文献
Brubaker; DeRuiter; Whitmer
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 1094 - 1099
反应条件
1: 64 percent / conc. H2SO4 2: 75 percent / conc. H2SO4 3: 96 percent / conc. NH4OH / 25 °C View Scheme
参考文献
Brubaker; DeRuiter; Whitmer
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 1094 - 1099
反应条件
1: 64 percent / conc. H2SO4 2: 75 percent / conc. H2SO4 3: 96 percent / conc. NH4OH / 25 °C View Scheme
参考文献
Brubaker; DeRuiter; Whitmer
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 1094 - 1099
反应条件
protein tyrosine phosphatases enzyme-induced hydrolysis; Enzymatic reaction; Kinetics;
参考文献
Holmes, Christopher P.; Macher, Natalie; Grove, J. Russell; Jang, Larry; Irvine, Jennifer D.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3382 - 3385
