2-甲基-4-甲氧基苯胺合成路线 （共 58 条）
反应条件
sulfuric acid T=25°C; durch wochenlange Einw.;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 390, p. 175
Chemische Berichte, , vol. 40, p. 1903
参考文献
Chemische Berichte, , vol. 58, p. 41
反应条件
1: aqueous H2SO4 / Diazotization.Behandlung der Diazoniumsalz-Loesung mit KI 2: sodium hydroxide; aqueous potassium permanganate View Scheme
参考文献
Sletzinger; Dawson
Journal of Organic Chemistry, 1949 , vol. 14, p. 670,678
反应条件
1: 1.) aq. NaNO2, 21percent aq. HBF4, 2.) NaF / 2.) 1,2,4-trichlorobenzene, 150 deg C 2: 51 percent / KMnO4 / pyridine; H2O / 2 h / 50 °C View Scheme
参考文献
Hartmann; Heindl; Schonenberger
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 577 - 585
反应条件
potassium phosphate; N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine; tris(dibenzylideneacetone)dipalladium (0) in toluene T=110°C; Buchwald-Hartwig amination; 8 h;
参考文献
Buchwald, Stephen L.; Mauger, Christelle; Mignani, Gerard; Scholz, Ulrich
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 1-2 p. 23 - 39
反应条件
caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; tris(dibenzylideneacetone)dipalladium (0) in toluene T=110°C; Buchwald-Hartwig amination;
参考文献
Buchwald, Stephen L.; Mauger, Christelle; Mignani, Gerard; Scholz, Ulrich
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 1-2 p. 23 - 39
参考文献
Mitsui Toatsu Chemicals, Inc.
Patent: US4804783 A1, 1989 ;
反应条件
4-(N,N-dimethlyamino)pyridine in hexane; dichloromethane; N,N-dimethyl acetamide; ethyl acetate
参考文献
Gungor, Timur; Corte, James R.
Patent: US2003/220227 A1, 2003 ;
US 20030220227 A1
反应条件
acetic acid; sodium nitrite in water T=20°C;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1403255 A1, 2004 ;
Location in patent: Page 44 ;
EP 1403255 A1
反应条件
1: (i) aq. HBF4, aq. NaNO2, (ii) (thermolysis) 2: aq. HBr, AcOH / Heating View Scheme
参考文献
Dat-Xuong,N. et al.
Chimica Therapeutica, 1967 , vol. 2, p. 53 - 56
