1,1,3,3-四甲氧基丙烷合成路线 （共 127 条）
反应条件
1: With boron trifluoride diethyl etherate T=0°C; 3 h; 2: With lithium aluminium tetrahydride in diethyl ether T=0 - 20°C; 3 h;
参考文献
Tetrahedron Letters, , vol. 53, # 40 p. 5360 - 5363
反应条件
1: boron trifluoride diethyl etherate / 3 h / 0 °C / Inert atmosphere; Neat (no solvent) 2: lithium aluminium tetrahydride / diethyl ether / 3 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 14, # 7 p. 1946 - 1948
反应条件
hydrogenchloride in methanol T=20°C; 72 h;
参考文献
Meigh; Alvarez; Joule
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 17 p. 2012 - 2021
参考文献
Ferrania Technologies S.p.A.
Patent: EP1810998 A2, 2007 ;
Location in patent: Page/Page column 7-8; 9; 12 ;
反应条件
triethylamine in N,N-dimethyl-formamide T=100°C; 14 h;
参考文献
GENENTECH, INC.; GIBBONS, Paul; HANAN, Emily; LIU, Wendy; LYSSIKATOS, Joseph P.; MAGNUSON, Steven R.; MENDONCA, Rohan; PASTOR, Richard; RAWSON, Thomas E.; SIU, Michael; ZAK, Mark E.; ZHOU, Aihe; ZHU, Bing-Yan
Patent: WO2011/3065 A2, 2011 ;
Location in patent: Page/Page column 110-111 ;
WO 2011/003065 A2
反应条件
hydrogenchloride; bromine
参考文献
Francisco, Gerardo D.; Li, Zhong; Albright, J. Donald; Eudy, Nancy H.; Katz, Alan H.; Petersen, Peter J.; Labthavikul, Pornpen; Singh, Guy; Yang, Youjun; Rasmussen, Beth A.; Lin, Yang-I.; Mansour, Tarek S.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 235 - 238
反应条件
hydrogenchloride in ethanol T=75°C; 2 h;
参考文献
Roppe, Jeffrey; Smith, Nicholas D.; Huang, Dehua; Tehrani, Lida; Wang, Bowei; Anderson, Jeffrey; Brodkin, Jesse; Chung, Janice; Jiang, Xiaohui; King, Christopher; Munoz, Benito; Varney, Mark A.; Prasit, Petpiboon; Cosford, Nicholas D. P.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4645 - 4648
反应条件
1: 5-bromo-2-nitrobenzaldehyde With hydrogenchloride; iron in methanol; water T=70°C; 2: malonaldehyde bis(dimethyl acetal) With hydrogenchloride in water T=80°C; 1.75 h; 3: With acetic acid in water; toluene T=110°C; 3 h;
参考文献
AMGEN INC.; CHENG, Yuan; POWERS, Timothy; ASHTON, Kate; BROWN, James; HARRIED, Scott; HITCHCOCK, Stephen; JUDD, Ted; LOPEZ, Patricia; NIXEY, Thomas; PARAS, Nick A,; POON, Steve F.; ST. JEAN JR., David J.; XUE, Qiufen; ZHONG, Wenge
Patent: WO2011/63233 A1, 2011 ;
Location in patent: Page/Page column 32 ;
WO 2011/063233 A1
反应条件
hydrogenchloride; sodium hydroxide; sodium dihydrogenphosphate
1.) 2 h, 2.) methanol, 3 d; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bertz, Steven H.
Journal of Organic Chemistry, 1985 , vol. 50, # 19 p. 3585 - 3592
反应条件
hydrogenchloride in water
参考文献
Nakaike, Yumi; Hayashi, Daisuke; Nishiwaki, Nagatoshi; Tobe, Yoshito; Ariga, Masahiro
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 2 p. 325 - 334
