1,1,3,3-四甲氧基丙烷合成路线 （共 127 条）
反应条件
in ethanol
4 h; Heating;
参考文献
Singh, S. P.; Kumar, Savita; Kumar, Devinder
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993 , vol. 32, # 2 p. 262 - 265
反应条件
hydrogenchloride; zinc(II) chloride
1) C2H5OH, reflux; 2) C2H5OH, 1 h, reflux; Yield given. Multistep reaction;
参考文献
Khan, Misbahul A.; Rolim, Alice M. C.
Monatshefte fuer Chemie, 1983 , vol. 114, p. 1079 - 1086
反应条件
hydrogen bromide; acetic anhydride; zinc(II) chloride in acetic acid
参考文献
Merck and Co., Inc.
Patent: US4234590 A1, 1980 ;
反应条件
1: With trimethylsilyl trifluoromethanesulfonate in dichloromethane
T=-78 - 20°C;
2: With hydrogenchloride in dichloromethane
Further stages.;
参考文献
Sher, Muhammad; Tam Dang; Ahmed, Zafar; Rashid, Muhammad A.; Fischer, Christine; Langer, Peter
Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6284 - 6286
反应条件
trifluoroacetic acid in Sec-butyl alcohol
4 h; Heating;
参考文献
Mlakar, Biserka; Stefane, Bogdan; Kocevar, Marijan; Polanc, Slovenko
Heterocycles, 1998 , vol. 48, # 5 p. 961 - 973
反应条件
hydrogenchloride; water
37 deg C, 48 h, at pH 9.5; Yield given. Multistep reaction;
参考文献
Kikugawa, Kiyomi; Maruyama, Teppei; Machida, Yasuko; Kurechi, Tsutao
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 5 p. 1423 - 1432
反应条件
1: 4-amino-2-methoxy-benzoic acid methyl ester With hydrogenchloride; sodium nitrite in water
T=0°C; 0.333333 h;
2: With tin(ll) chloride in water
T=0°C; 1.5 h;
3: malonaldehyde bis(dimethyl acetal); ethanol in ethanol
Heating / reflux;
参考文献
SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC
Patent: WO2005/63756 A1, 2005 ;
Location in patent: Page/Page column 19 ;
WO 2005/063756 A1
反应条件
in ethanol
6 h; Heating / reflux;
参考文献
SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC
Patent: WO2005/63755 A1, 2005 ;
Location in patent: Page/Page column 17; 27-28 ;
WO 2005/063755 A1
反应条件
1: 80 percent / 6N HCl / CHCl3 / 48 h / Ambient temperature
2: 90 percent / oxalic acid, silica gel / 1,2-dichloro-ethane; tetrahydrofuran / 10 h / 80 °C
View Scheme
参考文献
Shi-Qi, Peng; Winterfeldt, Ekkehard
Liebigs Annalen der Chemie, 1989 , p. 1045 - 1047
反应条件
trifluoroacetic acid in Sec-butyl alcohol
8.5 h; Heating;
参考文献
Mlakar, Biserka; Stefane, Bogdan; Kocevar, Marijan; Polanc, Slovenko
Heterocycles, 1998 , vol. 48, # 5 p. 961 - 973
