反应条件
N-protected phenylalanine; 9-fluorenylmethyloxycarbonyl-compd. in tetrahydrofuran
Ar atmosphere; addn. of N-methylmorpholine and isobutylchloroformate to soln. of amino acid (stirring, 0°C), pptn., stirring (10 min), filtration (-78°C), dropwise addn. of Fe-complex in THF (-78°C, stirring), stirring (2 h); warming to room temp., neutralization (aq. NH4Cl), sepn. of org. phase, drying (over MgSO4), filtration, evapn., column chromy. (silica, cyclohexane/CH2Cl2 2:1); elem. anal.;
参考文献
Amiens, C.; Balavoine, G.; Guibe, F.
Journal of Organometallic Chemistry, 1993 , vol. 443, # 2 p. 207 - 219
