反应条件
1: 83 percent / TEA / dioxane; H2O / 24 h / 25 °C
2: 1.) NaH / 1.) DMF, from 0 deg C to 25 deg C, 1 h, 2.) DMF, from -23 deg C to 0 deg C, 3 h
3: BBr3 / CH2Cl2 / 7 h / Ambient temperature
4: imidazole / dimethylformamide / 24 h / -23 - 25 °C
5: 81 percent / NaNO2, aq. HCl / tetrahydrofuran / 3 h / 0 °C
6: 66 percent / HF, NaF / tetrahydrofuran / 24 h / 25 °C
View Scheme
参考文献
Watanabe, Takumi; Takeuchi, Tomio; Otsuka, Masami; Umezawa, Kazuo
Journal of the Chemical Society, Chemical Communications, 1994 , # 4 p. 437 - 438