2-氨基-3-甲氧基吡啶合成路线 （共 16 条）
反应条件
sodium hydrogencarbonate in ethanol 8 h; Heating;
参考文献
Rydzkowski, Richard; Blondeau, Dominique; Sliwa, H.; Caze, Claude
Journal of Chemical Research, Miniprint, 1986 , # 2 p. 670 - 688
反应条件
1.1: bromine / acetic acid / 16.5 h / 20 °C 1.2: 0 °C / pH 7 2.1: bromine; sodium nitrite; hydrogen bromide / water / 1.33 h / 0 °C 2.2: 1 h / 20 °C / pH 13 View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2011/81316 A1, 2011 ;
反应条件
1.1: bromine / acetic acid / 16.5 h / 20 °C 1.2: 0 °C / pH 7 2.1: bromine; sodium nitrite; hydrogen bromide / water / 1.33 h / 0 °C 2.2: 1 h / 20 °C / pH 13 3.1: methanol / 3 h / 75 °C 4.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 9 h / 20 - 40 °C / Inert atmosphere View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2011/81316 A1, 2011 ;
反应条件
1: With N-chloro-succinimide in ethyl acetate
T=20°C; Protection from light;
2: With sodium hydrogensulfite in water; ethyl acetate
参考文献
ERRICO, Joseph P.; MUGRAGE, Benjamin; TURCHI, Ignatius; SILLS, Matthew; ONG, Jane; ALLOCCO, John; WINES, Pam
Patent: WO2011/85126 A2, 2011 ;
Location in patent: Page/Page column 162 ;
WO 2011/085126 A1
反应条件
1.1: bromine; sulfuric acid; acetic acid / water / 2 h / 3 - 5 °C
1.2: pH 8 / |Cooling with ice
2.1: potassium acetate; tris-(dibenzylideneacetone)dipalladium(0); tri-cyclo-hexyl-phosphine / 1,4-dioxane / 6 h / 110 °C / |Inert atmosphere
View Scheme
参考文献
Huang, Zilin; Jin, Jeff; Machajewski, Timothy; Antonios-McCrea, William R.; McKenna, Maureen; Poon, Daniel; Renhowe, Paul A.; Sendzik, Martin; Shafer, Cynthia; Smith, Aaron; Xu, Yongjin; Zhang, Qiong; Chen, Zheng
Patent: US2013/210818 A1, 2013 ;
反应条件
1: 97 percent / dioxane
2: 78 percent / NH2OH; DMAP / methanol; ethanol
3: 49 percent / KIO3; H2SO4 / 4 h / 120 °C
View Scheme
参考文献
Nettekoven, Matthias; Puellmann, Bernd; Schmitt, Sebastien
Synthesis, 2003 , # 11 p. 1649 - 1652
