2-氨基-4-甲氧基吡啶合成路线 （共 20 条）
反应条件
in methanol T=145 - 150°C; 7 h;
参考文献
Journal of Organometallic Chemistry, , vol. 523, # 2 p. 145 - 151
反应条件
hydrazine in methanol Curtius rearrangement; RefluxInert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 8 p. 3076 - 3080
反应条件
copper acetylacetonate; potassium phosphate; ammonia in N,N-dimethyl-formamide T=90°C; 24 h; GloveboxAutoclave; chemoselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 355, # 4 p. 627 - 631
反应条件
1: Ts2O / various solvent(s); CH2Cl2 / 0.25 h 2: TFA / various solvent(s); CH2Cl2 / 70 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 72, # 12 p. 4554 - 4557
反应条件
potassium hydroxide; bromine in 1,4-dioxane T=20 - 55°C; Hofmann degradation; 1.5 h;
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , # 17 p. 2012 - 2021
反应条件
trifluoroacetic anhydride in toluene 5 h; Heating;
参考文献
Organic Preparations and Procedures International, , vol. 29, # 1 p. 117 - 122
反应条件
1.1: thionyl chloride / sodium bromide / 24 h / Reflux 2.1: 24 h / 0 °C / Reflux 3.1: hydrazine / methanol / 4 h / Reflux 4.1: trifluoroacetic acid; tert.-butylnitrite / tetrahydrofuran 5.1: toluene / Reflux 5.2: 5 h / 20 °C View Scheme
反应条件
hydrogenchloride 8 h; Heating;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 28, # 2 p. 465 - 472
反应条件
1: t-BuONO, TFAA / tetrahydrofuran / 0.5 h / 0 °C 2: toluene / 1.) reflux, 1 h, 2.) reflux, 10 h 3: 67 percent / TFAA / toluene / 5 h / Heating View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 29, # 1 p. 117 - 122
