1: 4-chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline in isopropyl alcohol; toluene T=20°C; 1 h; 2: para-fluoro-meta-chloroaniline in isopropyl alcohol; toluene T=66°C; 1 h; 3: With sodium hydroxide in water; isopropyl alcohol; toluene T=64°C; Alkaline aqueous solution;