反应条件
1: 69 percent / piperidine / 1.) 100 deg C, 2 h, 2.) 155 deg C, 1 h
2: 95 percent / H2 / 10 percent Pd/C / tetrahydrofuran / 5 h / 2585.7 Torr
3: 98 percent / 1 M BH3*THF / tetrahydrofuran / 2 h / Ambient temperature
4: 1.) oxalyl chloride, Me2SO, 2.) NEt3 / 1.) CH2Cl2, -60 deg C, 10 min, 2.) CH2Cl2, -60 deg C, 5 min
View Scheme
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
