1: With ammonium chloride in tetrahydrofuran; methanol T=0°C; 0.5 h; Inert atmosphere; 2: With zinc in tetrahydrofuran; methanol T=20°C; 4 h; Inert atmosphere;

1: (Bromomethyl)triphenylphosphonium bromide With lithium hexamethyldisilazane in tetrahydrofuran T=-15°C; 0.25 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran T=20°C; 2 h;

1.1: triphenylphosphine / dichloromethane / 72 h / 0 - 20 °C / |Inert atmosphere 2.1: ammonium chloride / tetrahydrofuran; methanol / 0.5 h / 0 °C / |Inert atmosphere 2.2: 4 h / 20 °C / |Inert atmosphere View Scheme