2-(2-氰基-乙烯基氨基)-丙二酸二乙酯合成路线 （共 6 条）
反应条件
1: isoxazole acid With sodium ethanolate in ethanol T=0°C; 0.5 h; 2: aminomalonic acid diethyl ester hydrochloride With sodium acetate; acetic acid in ethanol T=20°C; 48 h;
参考文献
Heald, Robert; Price, Stephen; Safina, Brian; Savy, Pascal Pierre Alexandre; Seward, Eileen Mary; Sutherlin, Daniel P.; Waszkowycz, Bohdan
Patent: US2012/202785 A1, 2012 ;
Location in patent: Page/Page column 128 ;
反应条件
sodium acetate in acetic acid T=20°C; Condensation; 48 h;
参考文献
Furneaux, Richard H.; Tyler, Peter C.
Journal of Organic Chemistry, 1999 , vol. 64, # 22 p. 8411 - 8412
反应条件
sodium acetate; acetic acid in ethanol T=20°C; pH=6 - 7; 48 h;
参考文献
Wu, Xiaoqing; Li, Mingdong; Tang, Wenhua; Zheng, Youguang; Lian, Jiqin; Xu, Liang; Ji, Min
Chemical Biology and Drug Design, 2011 , vol. 78, # 6 p. 932 - 940
反应条件
1: sodium ethanolate / ethanol / 72 h / 20 °C 2: ethanol / 16 h / Reflux 3: trichlorophosphate / 1 h / Reflux View Scheme
反应条件
1: sodium ethoxide / ethanol / 72 h / 20 °C 2: 11.8 g / ethanol / 16 h / Heating View Scheme
参考文献
Heald, Robert; Price, Stephen; Safina, Brian; Savy, Pascal Pierre Alexandre; Seward, Eileen Mary; Sutherlin, Daniel P.; Waszkowycz, Bohdan
Patent: US2012/202785 A1, 2012 ;
反应条件
1: With sodium ethanolate in ethanol T=20°C; 72 h; 2: With acetic acid in ethanol 3: With sodium hydrogencarbonate in dichloromethane; water
参考文献
Heald, Robert; Price, Stephen; Safina, Brian; Savy, Pascal Pierre Alexandre; Seward, Eileen Mary; Sutherlin, Daniel P.; Waszkowycz, Bohdan
Patent: US2012/202785 A1, 2012 ;
Location in patent: Page/Page column 128-129 ;
