(3S)-3-(叔丁氧羰基)氨基-1-氯-4-苯基-2-丁酮合成路线 （共 24 条）
反应条件
1: 97 percent / NaI / dimethylformamide / 18 h / Ambient temperature 2: 72 percent / aq. K2CO3 / methanol / 3.5 h 3: NaBH4 / tetrahydrofuran; methanol / 1 h / 0 °C View Scheme
参考文献
Remuzon, Philippe; Dussy, Christian; Jacquet, Jean-Pierre; Roty, Pascale; Bouzard, Daniel
Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 1181 - 1188
反应条件
1: With formic acid; triethylamine; (pentamethylcyclopentadienyl)RhCl[(S,S)-Tsdpen] in isopropyl alcohol T=25°C; 2: With sodium hydroxide in isopropyl alcohol T=0°C; 3: With water
参考文献
Journal of Organic Chemistry, , vol. 69, # 21 p. 7391 - 7394
反应条件
1: 7.8 g / NaBH4 / toluene; ethanol / 8 h / -78 - 0 °C 2: 89 percent / KOH / ethanol / 2 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 21 p. 7344 - 7347
反应条件
1: aluminum isopropoxide / isopropyl alcohol / 3 h / |Reflux 2: sodium carbonate / water / 3 h / 60 - 65 °C 3: triethylamine / dichloromethane / 40 - 45 °C View Scheme
参考文献
MYLAN LABORATORIES LTD; VELLANKI, Siva Rama Prasad; SAHU, Arabinda; PHADHURI, Naveen Kumar; KILARU, Ravindrababu
Patent: WO2013/114382 A1, 2013 ;
反应条件
1: With formic acid; triethylamine; (pentamethylcyclopentadienyl)RhCl[(S,S)-Tsdpen] in isopropyl alcohol T=25°C; 2: With sodium hydroxide in isopropyl alcohol T=0°C; 3: With water
参考文献
Journal of Organic Chemistry, , vol. 69, # 21 p. 7391 - 7394
反应条件
1: 7.8 g / NaBH4 / toluene; ethanol / 8 h / -78 - 0 °C 2: 89 percent / KOH / ethanol / 2 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 21 p. 7344 - 7347
反应条件
isopropyl alcohol; Al tri-t-BuO- in dichloromethane T=50°C; Meerwein-Ponndorf-Verley Reduction; Inert atmosphere; Product distribution / selectivity;
参考文献
AMERICAN PACIFIC CORPORATION; LIOTTA, Charles, L.; POLLET, Pamela; KITAGAWA, Kristen; DUBAY, William; STRINGER, Joy
Patent: WO2011/60302 A1, 2011 ;
Location in patent: Page/Page column 20 ;
反应条件
sodium tetrahydroborate in tetrahydrofuran; water T=0°C; 0.75 h;
参考文献
Barrish, Joel C.; Gordon, Eric; Alam, Masud; Lin, Pin-Fang; Bisacchi, Gregory S.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1758 - 1768
反应条件
diisobutylaluminium hydride in toluene
参考文献
KANEKA CORPORATION
Patent: EP1151992 A1, 2001 ;
反应条件
sodium borohydride in tetrahydrofuran; water; ethyl acetate
参考文献
Kronenthal, David; Schwinden, Mark D.
Patent: US2002/26079 A1, 2002 ;
