(3S)-3-(叔丁氧羰基)氨基-1-氯-4-苯基-2-丁酮合成路线 （共 24 条）
反应条件
potassium phosphate buffer; Streptomyces nodosus SC 13149 T=28°C; microbial reduction; pH=6.8; 48 h;
参考文献
Patel, Ramesh N.
JAOCS, Journal of the American Oil Chemists' Society, 1999 , vol. 76, # 11 p. 1275 - 1281
反应条件
1.1: hydrogenchloride / tetrahydrofuran / 4 h / 50 °C 2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -25 - 20 °C 3.1: sodium iodide / acetonitrile / 0.25 h / 20 °C 3.2: 0.25 h / 20 °C 4.1: lithium tri-t-butoxyaluminum hydride / diethyl ether / 4 h / 0 °C View Scheme
参考文献
Fan, Xing; Song, Yan-Li; Long, Ya-Qiu
Organic Process Research and Development, 2008 , vol. 12, # 1 p. 69 - 75
反应条件
1.1: hydrogenchloride / tetrahydrofuran / 4 h / 50 °C 2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -25 - 20 °C 3.1: sodium iodide / acetonitrile / 0.25 h / 20 °C 3.2: 0.25 h / 20 °C 4.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 0 °C View Scheme
参考文献
Fan, Xing; Song, Yan-Li; Long, Ya-Qiu
Organic Process Research and Development, 2008 , vol. 12, # 1 p. 69 - 75
反应条件
1.1: aluminum isopropoxide / isopropyl alcohol / 3 h / |Reflux 2.1: sodium carbonate / water / 3 h / 60 - 65 °C 3.1: triethylamine / dichloromethane / 40 - 45 °C 4.1: palladium 10 on activated carbon; hydrogen; triethanolamine / isopropyl alcohol / 3 h / 40 - 45 °C / 3000.3 - 4500.45 Torr 4.2: |Reflux View Scheme
参考文献
MYLAN LABORATORIES LTD; VELLANKI, Siva Rama Prasad; SAHU, Arabinda; PHADHURI, Naveen Kumar; KILARU, Ravindrababu
Patent: WO2013/114382 A1, 2013 ;
