5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲腈合成路线 （共 3 条）
反应条件
1: With sodium hydroxide; water T=20 - 90°C; 2: With hydrogenchloride; water T=60°C; 0.666667 h;
参考文献
SHANGHAI DE NOVO PHARMATECH CO LTD.; Gao, Daxin
Patent: US2013/224107 A1, 2013 ;
Location in patent: Paragraph 0143; 0144; 0145 ;
反应条件
1: water; hydrogenchloride / 20 °C
2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C
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参考文献
SHANGHAI DE NOVO PHARMATECH CO LTD.; Gao, Daxin
Patent: US2013/224107 A1, 2013 ;
反应条件
Multi-step reaction with 2 steps 1: water; hydrogenchloride / 20 °C2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C
参考文献
SHANGHAI DE NOVO PHARMATECH CO LTD.; Gao, Daxin Patent: US2013/224107 A1, 2013 ;
